Publications

2021

  1. Miska J, Rashidi A, Lee-Chang C, Gao P, Lopez-Rosas A, Zhang P, Burga R, Castro B, Xiao T, Han Y, Hou D, Sampat S, Cordero A, Stoolman JS, Horbinski CM, Burns M, Reshetnyak YK, Chandel NS, Lesniak MS. Polyamines drive myeloid cell survival by buffering intracellular pH to promote immunosuppression in glioblastoma. Sci Adv. 2021, 7(8), eabc8929.

2020

  1. Wu H, Estrella V, Beatty M, Abrahams D, El-Kenawi A, Russell S, Ibrahim-Hashim A, Longo DL, Reshetnyak YK, Moshnikova A, Andreev OA, Luddy K, Damaghi M, Kodumudi K, Pillai SR, Enriquez-Navas P, Pilon-Thomas S, Swietach P, Gillies RJ (2020) T-cells produce acidic niches in lymph nodes to suppress their own effector functions. Nat Commun. 11(1), 4113.
  2. Crawford T, Moshnikova A, Roles S, Weerakkody D, DuPont M, Carter LM, Shen J, Engelman DM, Lewis JS, Andreev OA, Reshetnyak YK. pHLIP ICG for delineation of tumors and blood flow during fluorescence-guided surgery. Sci Rep. 2020, 27, 10(1), 18356.
  3. Slaybaugh G, Weerakkody D, Engelman DM, Andreev OA, Reshetnyak YK. Kinetics of pHLIP peptide insertion into and exit from a membrane. Proc Natl Acad Sci USA.
    2020 pii: 201917857.
  4. Henry KE, Chaney AM, Nagle VL, Cropper HC, MozaffariS, Slaybaugh G, Parang K, Andreev OA, Reshetnyak YK, James ML, Lewis JS. Demarcation of Sepsis-Induced Perpherial and Central Acidosis with pH-Low Insertion Cyclic (pHLIC) Peptide. J Nuck Med.
    2020, pii: jnumed.119.233072 [Epub ahead of print].
  5. Reshetnyak YK, Moshnikova A, Andreev OA, Engleman DM. Targeting Acidic Diseased Tissues by pH Triggered Membrane-Associated Peptide Folding. Front Bioeng Biotechnol. 8, 335 2020
  6. Brito J, Golijanin B, Kott O, Moshnikova A, Mueller-Leonhard C, Gershman B, Andreev OA, Reshetnyak YK, Amin A, Golijanin D. Ex-vivo Imaging of Upper Tract Urothelial Carcinoma Using Novel pH Low Insertion Peptide (Variant 3), a Molecular Imaging Probe. Urology 139, 135-140. 2020

2019

  1. Sahraei, M et al. Suppressing miR-21 activity in tumor-associated macrophages promotes an antitumor immune response J Clin Invest. 2019 Nov. 11. doi: 10.1172/JCI127125
    JCI
  2. Price, NL et al. Genetic deficiency or pharmacological inhibition of miR-33 protects from kidney fibrosis. JCI Insight 2019 Oct 15. doi: 10.1172/jci.insight.131102
    Pub Med
  3. Roberts, et al. Acid specific dark quencher QC1 pHLIP for multi-spectral optoacoustic diagnoses of breast cancer. Sci Rep 2019 Jan 18. doi: 10.1038/s41598-019-44873-1
    Pub Med
  4. Brito J, Golijanin B, Kott O, Moshnikova A, Mueller-Leonhard C, Gershman B, Andreev OA, Reshetnyak YK, Amin A, Golijanin D. Ex-vivo Imaging of Upper Tract Urothelial Carcinoma Using Novel ICG-Var3 pHLIP Imaging Agent. Urology. 2019 Jan 16. pii: S0090-4295(19)30061-5.
    Science Direct
  5. Wei D, Engelman DM, Reshetnyak YK, Andreev OA. Mapping pH at Cancer Cell Surfaces. Mol Imaging Biol. 2019 Apr 11. doi: 10.1007/s11307-019-01335-4. In press.
    Springer Link

2018

  1. Rinaldi F, Hanieh P, Favero E, Rondelli V, Brocca P, Pereira M, Andreev OA, Reshetnyak YK, Marianecci C, Carafa M. Decoration of Nanovesicales with pH (Low) Insertion Peptide (pHLIP) for Targeted Delivery. Nanoscale Research Letters 2018 13:391.
    PubMed
  2. Karabadzhak AG, Weerakkody D, Deacon J, Andreev OA, Reshetnyak YK, Engelman DM. Bilayer Thickness and Curvature Influence Binding and Insertion of a pHLIP Peptide. Biophys J. 2018 May 8;114(9):2107-2115.
    PubMed
  3. Vila-Vicosa D, Silva TFD, Slaybaugh G, Reshetnyak YK, Andreev OA, Machuqueiro M. The membrane-induced p K(a) shifts in wt-pHLIP and its L16H variant. J Chem Theory Comput (2018) doi: 10.1021/acs.jctc.8b00102.
    PubMed
  4. Wyatt LC, Moshnikova A, Crawford T, Engelman DM, Andreev OA and Reshetnyak YK. Peptides of pHLIP family for targeted intracellular and extracellular delivery of cargo molecules to tumors. PNAS (2018) doi:10.1073/pnas.1715350115.
    PNAS

2017

  1. Pereira MC, Pianella M, Wei D, et al. pH-sensitive pHLIP® coated niosomes. Mol Membr Biol (2017) doi:10.1080/09687688.2017.1342969.
    Taylor & Francis Online
  2. Daniels JL, Crawford TM, Andreev OA, and Reshetnyak YK. Synthesis and Characterization of pHLIP® Coated Gold Nanoparticles. Biochem Biophys Rep (2017) doi:10.1016/j.bbrep.2017.02.008.
    ScienceDirect
  3. Wyatt LC, Lewis JS, Andreev OA, Reshetnyak YK, and Engelman DM. Applications of pHLIP Technology for Cancer Imaging and Therapy. Trends Biotechnol (2017) doi:10.1016/j.tibtech.2017.03.014.
    PubMed

2016

  1. Narayanan T, Weerakkody D, Karabadzhak AG, et al. pHLIP® Peptide Interaction With Membrane Monitored by SAXS. J Phys Chem B (2016) doi:10.1021/acs.jpcb.6b06643.
    PubMed
  2. Weerakkody D, Andreev OA, and Reshetnyak, YK. Insertion into Lipid Bilayer of Truncated pHLIP® Peptide. Biochem Biophys Rep (2016) doi:10.1016/j.bbrep.2016.10.001.
    Science Direct
  3. Golijanin J, Amin A, Moshnikova A, et al. Targeted imaging of urothelium carcinoma in human bladders by an ICG pHLIP peptide ex vivo. Proc Natl Acad Sci USA (2016) doi:10.1073/pnas.1610472113.
    PubMed
  4. Weerakkody, D. et al. Novel pH-Sensitive Cyclic Peptides. Sci. Rep. 6, 31322; doi:10.1038/srep31322 (2016).
    Scientific Reports
  5. Demoin DW, Wyatt LC, Edwards KJ, et al. “PET Imaging of Extracellular pH in Tumors with 64Cu- and 18F-labeled pHLIP peptides: A Structure-Activity Optimization Study.” Bioconjugate Chemistry. (2016) doi:10.1021/acs.bioconjchem.6b00306
    Bioconjugate Chemistry
  6. Anderson M, Moshnikova A, Engelman DM, Reshetnyak YK, Andreev, OA. “Probe for the measurement of cell surface pH in vivo and ex vivo.” PNAS (2016) doi:10.1073/pnas.1608247113
    PNAS
  7. Samana Shrestha et al. Gold Nanoparticles for Radiation Enhancement in Vivo. J J Rad Oncol. 2016, 3(1): 026.
    Free Text
  8. Adochite RC, Moshnikova A, Golijanin J, Andreev OA, Katenka NV, Reshetnyak YK.; “Comparative Study of Tumor Targeting and Biodistribution of pH (Low) Insertion Peptides (pHLIP® Peptides) Conjugated with Different Fluorescent Dyes.” Mol Imaging Biol (2016) doi:10.1007/s11307-016-0949-6
    Springer

2015

  1. Tapmeier TT, Moshnikova A, Beech J, Allen D, Kinchesh P, Smart S, Harris A, McIntyre A, Engelman DM, Andreev OA, Reshetnyak YK, Muschel RJ.; “The pH low insertion peptide pHLIP Variant 3 as a novel marker of acidic malignant lesions.” PNAS (2015)
    PNAS
  2. Reshetnyak YK.; “Imaging Tumor Acidity: pH-Low Insertion Peptide Probe for Optoacoustic Tomography” Clin Cancer Res.; 2015 Jul 29 pii: clincanres.1502.2015. [Epub ahead of print]
    Clinical Cancer Research
  3. Ganga P Sharma, Yana K Reshetnyak, Oleg A Andreev, Michael Karbach and Gerhard Müller; “Coil-helix transition of polypeptide at water-lipid interface” J. Stat. Mech. (2015) DOI: 10.1088/1742-5468/2015/01/P01034
    IOP Science
  4. Arachchige, MCM, et al., “Advanced targeted nanomedicine.” J. Biotechnol. (2015)
    ScienceDirect
  5. Michael P. Antosh, Dayanjali D. Wijesinghe, Samana Shrestha, Robert Lanou, Yun Hu Huang, Thomas Hasselbacher, David Fox, Nicola Neretti, Shouheng Sun, Natallia Katenka, Leon N Cooper, Oleg A. Andreev, and Yana K. Reshetnyak; “Enhancement of radiation effect on cancer cells by gold-pHLIP” PNAS (2015)
    PNAS

2014

  1. Karabadzhak AG, An M, Yao L, Langenbacher R, Moshnikova A, Adochite RC, Andreev OA, Reshetnyak YK, and Engelman DM, “pHLIP-FIRE, a cell insertion-triggered fluorescent probe for imaging tumors demonstrates targeted cargo delivery in vivo.” ACS Chem Biol (2014) 9, 2545-53
    Free Text
  2. Ramona-Cosmina Adochite, Anna Moshnikova, Sean D. Carlin, Renato A. Guerrieri, Oleg A. Andreev, Jason S. Lewis, and Yana K. Reshetnyak, “Targeting Breast Tumors with pH (Low) Insertion Peptides” Molecular Pharmaceutics DOI: 10.1021/mp5002526
    Free Text
  3. Andreev OA, Engelman DM and Reshetnyak YK (2014) “Targeting diseased tissues by pHLIP insertion at low cell surface pH.” Front. Physiol. 5:97. doi: 10.3389/fphys.2014.00097
    Free Text
  4. Cruz-Monserrate, Z. et al. “Targeting Pancreatic Ductal Adenocarcinoma Acidic Microenvironment.” Sci. Rep. 4, 4410; DOI:10.1038/srep04410 (2014).
    Free Text
  5. Nerissa Therese Viola-Villegas, Sean D. Carlin, Ellen Ackerstaff, Kuntal K. Sevak, Vadim Divilov, Inna Serganova, Natalia Kruchevsky, Michael Anderson, Ronald G. Blasberg, Oleg A. Andreev, Donald M. Engelman, Jason A. Koutcher, Yana K. Reshetnyak, and Jason S. Lewis. “Understanding the pharmacological properties of a metabolic PET tracer in prostate cancer” PNAS 2014 doi: 10.1073/pnas.140524011
    Free Text

2013

  1. Dhammika Weerakkody, Anna Moshnikova, Mak S. Thakur, Valentina Moshnikova, Jennifer Daniels, Donald M. Engelman, Oleg A. Andreev, and Yana K. Reshetnyak, “Family of pH (low) insertion peptides for tumor targeting,” PNAS, Vol 110, No. 15 pp. 5834-5839, 2013.
    Free Text
  2. Lan Yao, Jennifer Daniels, Dayanjali Wijesinghe, Oleg A. Andreev, Yana K. Reshetnyak, “pHLIP Mediated Delivery of PEGylated Liposomes to Cancer Cells,” Journal of Controlled Release, Vol 167, pp. 228-237, 2013.
    PubMed
  3. Anna Moshnikova, Valentina Moshnikova, Oleg A. Andreev, Yana K. Reshetnyak, “Antiproliferative Effect of pHLIP-Amanitin,” Biochemistry, Vol 57, No. 7, pp. 1171-1178, 2013.
    PubMed
  4. Eugene A. Sosunov, Evgeny P. Anyukhovsky, Alexander A. Sosunov, Anna Moshnikova, Dayanjali Wijesinghe, Donald M. Engelmand, Yana K. Reshetnyak, and Oleg A. Andreev, “pH (low) insertion peptide (pHLIP) targets ischemic myocardium,” PNAS, Vol 110, No. 1, pp. 82-86, 2013.
    Free Text
  5. Lan Yao, Jennifer Daniels, Anna Moshnikova, Sergey Kuznetsov, Aftab Ahmed, Donald M. Engelman, Yana K. Reshetnyak, and Oleg A. Andreev, “pHLIP peptide targets nanogold particles to tumors,” PNAS, Vol 110, No. 2, pp. 465-470, 2013.
    Free Text
  6. Wijesinghe, D., Arachchige, M.C.M., Lu, A., Reshetnyak, Y.K. & Andreev, O.A. “pH dependent transfer of nano-pores into membrane of cancer cells to induce apoptosis.” Sci. Rep.3, 3560; DOI: 10.1038/srep03560 (2013).
    Free Text

2012

  1. Yana K. Reshetnyak, Cynthia N. Prudence, James Segala, Vladislav S. Markin, Oleg A. Andreev, “Parking problem and negative cooperativity of binding of myosin subfragment 1 to F-actin,” Biochemical and Biophysical Research Communications, Vol. 425, pp. 476-479, 2012.
    PubMed
  2. Pierre Daumar, Cindy Wanger-Baumann, Nagavara Pillarsetty, Laura A Fabrizio, Sean D Carlin, Yana K. Reshetnyak, Oleg A. Andreev, and Jason S. Lewis, “Efficient [18F]-Labeling of Large 37-Amino Acid pHLIP Peptide Analogues and their Biological Evaluation,” Bioconjugate Chemistry, pp. 1-45, 2012.
    Free Text
  3. Alexander G. Karabadzhak, Dhammika Weerakkody, Dayanjali Wijesinghe, Mak S. Thakur, Donald M. Engelman, Oleg A. Andreev, Vladislav S. Markin, and Yana K. Reshetnyak, “Modulation of the pHLIP Transmembrane Helix Insertion Pathway,” Biophysical Journal, vol. 102, pp. 1846-1855, 2012.
    Free Text
  4. Sven Macholl, Matthew S. Morrison, Peter Iveson, Bente E. Arbo, Oleg A. Andreev, Yana K. Reshetnyak, Donald M. Engelman, Edvin Johannesen, “In Vivo pH Imaging with 99mTc-pHLIP,” Molecular Imaging Biology, vol. 14, pp. 725-734, 2012.
    PubMed

2011

  1. Francisco N. Barrera, Dhammika Weerakkody, Michael Anderson, Oleg A. Andreev, Yana K. Reshetnyak and Donald M. Engelman, “Roles of Carboxyl Groups in the Transmembrane Insertion of Peptides,” Journal of Molecular Biology, vol. 413, pp. 359-371, 2011.
    Free Text
  2. Y. K. Reshetnyak, L. Yao, S. Zheng, S. Kuznetsov, D. M. Engelman and O. A. Andreev, “Measuring Tumor Aggressiveness and Targeting Metastatic Lesions with Fluorescent pHLIP,” Mol Imaging Biol, vol. 13, pp. 1146-1156, 2011.
    Free Text
  3. Dayanjali Wijesinghe, Donald M. Engelman, Oleg A. Andreev, and Yana K. Reshetnyak, “Tuning a Polar Molecule for Selective Cytoplasmic Delivery by a pH(Low) Insertion Peptide,” Biochemistry, vol. 50, pp. 10215-10222, 2011.
    Free Text
  4. Cynthia N. Prudence, Brad Boudreau, Yana K. Reshetnyak, “Protein Fluorescence Database,” Recent Researches in Chemistry, Biology, Environment and Culture, pp. 59-63, 2011.
    PDF

2010

  1. M. An, D. Wijesinghe, O. A. Andreev, Y. K. Reshetnyak and D. M. Engelman, “pH-(low)-insertion-peptide (pHLIP) translocation of membrane impermeable phalloidin toxin inhibits cancer cell proliferation,” Proc Natl Acad Sci U S A, vol. 107, no. 47, pp. 20246-50, 2010.
    Free Text
  2. O. A. Andreev, A. G. Karabadzhak, D. Weerakkody, G. O. Andreev, D. M. Engelman and Y. K. Reshetnyak, “pH (low) insertion peptide (pHLIP) inserts across a lipid bilayer as a helix and exits by a different path,” Proc Natl Acad Sci U S A, vol. 107, no. 9, pp. 4081-6, 2010.
    Free Text
  3. O. A. Andreev, D. M. Engelman and Y. K. Reshetnyak, “pH-sensitive membrane peptides (pHLIPs) as a novel class of delivery agents,” Mol Membr Biol, vol. 27, no. 7, pp. 341-52, 2010.
    PubMed
  4. M. Musial-Siwek, A. Karabadzhak, O. A. Andreev, Y. K. Reshetnyak and D. M. Engelman, “Tuning the insertion properties of pHLIP,” Biochim Biophys Acta, vol. 1798, no. 6, pp. 1041-6, 2010.
    Free Text
  5. L. Yao, J. Segala, A.J. Bucci, G.O. Andreev, Y.K. Reshetnyak, and O.A. Andreev, “Fluorescence anistropy imaging microscopy,” Microscopy: Science, Technology, Applications and Education, Formatex Research Center, 3, pp. 2072-8, 2010.
    ResearchGate

2009

  1. O. A. Andreev, D. M. Engelman and Y. K. Reshetnyak, “Targeting acidic diseased tissue: New technology based on use of the pH (Low) Insertion Peptide (pHLIP),” Chemistry Today, vol. 27, no. 2, pp. 34-37, 2009.
    Free Text
  2. J. Hixon, and Y. K. Reshetnyak, “Algorithm for the Analysis of Tryptophan Fluorescence Spectra and Their Correlation with Protein Structural Parameters,” Algorithms, vol. 2, pp. 1155-76, 2009.
    PubMed
  3. J. Segala, D. M. Engelman, Y. K. Reshetnyak and O. A. Andreev, “Accurate analysis of tumor margins using a fluorescent pH Low Insertion Peptide (pHLIP),” Int J Mol Sci, vol. 10, no. 8, pp. 3478-87, 2009.
    Free Text
  4. A. L. Vavere, G. B. Biddlecombe, W. M. Spees, J. R. Garbow, D. Wijesinghe, O. A. Andreev, D. M. Engelman, Y. K. Reshetnyak and J. S. Lewis, “A novel technology for the imaging of acidic prostate tumors by positron emission tomography,” Cancer Res, vol. 69, no. 10, pp. 4510-6, 2009.
    Free Text
  5. L. Yao, G. O. Andreev, Y. K. Reshetnyak and O. A. Andreev, “Fabrication of semiconductor nanowires by conjugation of quantum dots to actin filaments,” Anal Bioanal Chem, vol. 395, no. 5, pp. 1563-6, 2009.
    PubMed

2008

  1. N. Jain, Y. K. Reshetnyak, L. Gao, M. P. Chiarelli and B. P. Cho, “Fluorescence probing of aminofluorene-induced conformational heterogeneity in DNA duplexes,” Chem Res Toxicol, vol. 21, no. 2, pp. 445-52, 2008.
    Free Text
  2. Y. K. Reshetnyak, O. A. Andreev, M. Segala, V. S. Markin and D. M. Engelman, “Energetics of peptide (pHLIP) binding to and folding across a lipid bilayer membrane,” Proc Natl Acad Sci U S A, vol. 105, no. 40, pp. 15340-5, 2008.
    Free Text
  3. C. Shen, R. Menon, D. Das, N. Bansal, N. Nahar, N. Guduru, S. Jaegle, J. Peckham and Y. K. Reshetnyak, “The protein fluorescence and structural toolkit: Database and programs for the analysis of protein fluorescence and structural data,” Proteins, vol. 71, no. 4, pp. 1744-54, 2008.
    PubMed
  4. M. Zoonens, Y. K. Reshetnyak and D. M. Engelman, “Bilayer interactions of pHLIP, a peptide that can deliver drugs and target tumors,” Biophys J, vol. 95, no. 1, pp. 225-35, 2008.
    Free Text

2007

  1. O. A. Andreev, A. D. Dupuy, M. Segala, S. Sandugu, D. A. Serra, C. O. Chichester, D. M. Engelman and Y. K. Reshetnyak, “Mechanism and uses of a membrane peptide that targets tumors and other acidic tissues in vivo,” Proc Natl Acad Sci U S A, vol. 104, no. 19, pp. 7893-8, 2007.
    Free Text
  2. O. A. Andreev and Y. K. Reshetnyak, “Mechanism of formation of actomyosin interface,” J Mol Biol, vol. 365, no. 3, pp. 551-4, 2007.
    PubMed
  3. Y. K. Reshetnyak, M. Segala, O. A. Andreev and D. M. Engelman, “A monomeric membrane peptide that lives in three worlds: in solution, attached to, and inserted across lipid bilayers,” Biophys J, vol. 93, no. 7, pp. 2363-72, 2007.
    Free Text
  4. M. Torrent, E. Cuyas, E. Carreras, S. Navarro, O. Lopez, A. de la Maza, M. V. Nogues, Y. K. Reshetnyak and E. Boix, “Topography studies on the membrane interaction mechanism of the eosinophil cationic protein,” Biochemistry, vol. 46, no. 3, pp. 720-33, 2007.
    PubMed

2006

  1. O. A. Andreev, S. Sandugu, D. M. Engelman, and Y. K. Reshetnyak “Injection of Molecules into cells using a pH-triggered molecular nanosyringe,” Technical Proceed. of the 2006 Nanotech Conf., vol. 2, pp. 57-60, 2006.
    PDF – Slideshow
  2. Y. K. Reshetnyak, O. A. Andreev, U. Lehnert and D. M. Engelman, “Translocation of molecules into cells by pH-dependent insertion of a transmembrane helix,” Proc Natl Acad Sci U S A, vol. 103, no. 17, pp. 6460-5, 2006.
    Free Text
  3. Y. Reshetnyak, K. T. Tchedre, M. P. Nair, P. H. Pritchard and A. G. Lacko, “Structural differences between wild-type and fish eye disease mutant of lecithin:cholesterol acyltransferase,” J Biomol Struct Dyn, vol. 24, no. 1, pp. 75-82, 2006.
    PubMed

2004

  1. D. Linke, J. Frank, M. S. Pope, J. Soll, I. Ilkavets, P. Fromme, E. A. Burstein, and Y. Reshetnyak, “Folding Kinetics and Structure of OEP16,” Biophys.J., vol. 86, no. 3, pp. 1479-1487, 2004.
    Free Text
  2. Y.K. Reshetnyak, R. P. Kitson, M. Lu, and R. H. Goldfarb, “Conformational and enzymatic changes of 20S proteasome of rat natural killer cells induced by mono and divalent cations,” J. Struct. Biol., vol. 145, no. 3, pp. 263-71, 2004.
    PubMed